07:15 Registration
08:00 Program overview
Giovanni Barbara (Italy)
08:20 Plenary session (Palazzo Re Enzo)
SESSION I
Rome Foundation Symposium – What’s New in Rome V
Chairs:
Vincenzo Stanghellini (Italy)
Jan Tack (Belgium)
08:20 Rome Foundation related activities
Jan Tack (Belgium)
08:30 Recent pathophysiology insights relevant for IBS symptom generation
Madhusudan Grover (USA)
08:55 IBS in Rome V criteria: what’s new
Anthony Lembo (USA)
09:20 Centrally mediated disorders of gastrointestinal pain
Qasim Aziz (UK)
09:45 Coffee break
10:15 Plenary session (Palazzo Re Enzo)
SESSION II
Is it all IBS or maybe a different diagnosis?
Chairs:
Lin Chang (USA)
Maura Corsetti (Italy)
10:15 Bile acid metabolism and symptom generation
Michael Camilleri (USA)
10:40 Central or peripheral mechanisms underlying abdominal pains
Sigrid Elsenbruch (Germany)
11:05 The small intestine as a key player in symptom perception
Tim Vanyutsel (Belgium)
11:30 Plenary session (Palazzo Re Enzo)
SESSION III
Advances in IBS pathophysiology from large cohorts
Chairs:
Michael Camilleri (USA)
Roberto De Giorgio (Italy)
11:30 Genetics of IBS across definitions, subtypes, ethnicities, sexes and endophenotypes
Mauro D’Amato (Italy)
11:55 Food intolerance revisited: the GenMalCarb study
Maura Corsetti (UK)
12:20 Clinical highlights from the H2020 DISCOvERIE study
Magnus Simrén (Sweden)
12:45 Translational highlights from the H2020 DISCOvERIE study
Javier Santos (Spain)
13:00 Lunch break and Poster Session
Plenary session (Palazzo Re Enzo)
POSTER SESSION
Chairs:
Dan Dumitrascu (Romania)
Madhusudan Grover (USA)
Vasile Drug (Romania)
Paola Iovino (Italy)
Committee Members:
Lukas Balsiger (Switzerland)
Chiara Castellana (Italy)
Loris Lopetuso (Italy)
Hanne Matheussen (Belgium)
Nathalie Vergnolle (France)
Maria Raffaella Barbaro (Italy)
Luigi Colecchia (Italy)
Daniele Mandolesi (Italy)
Daniele Salvi (Italy)
14:10 Parallel sessions (different locations)
WORKSHOP 1
14:10 Main Congress Hall Salone del Podestà (Palazzo Re Enzo)
SPONSORED LECTURES
Chairs:
Massimo Bellini (Italy)
Jan Tack (Belgium)
14:10 BROMATECH SPONSORED LECTURE
Gut microbiota and probiotics for the integrity of the intestinal epithelial barrier
Giovanni Barbara (Italy)
14:35 BROMATECH SPONSORED LECTURE
Gut-vascular barrier modulation by strain-specific probiotics
Maria Rescigno (Italy)
15:00 BIOGAIA SPONSORED LECTURE
L. reuteri DSM 17938 and ATCC PTA 6475 in IBS: a translational approach
Magnus Simrén (Sweden)
15:20 Main Congress Hall Salone del Podestà (Palazzo Re Enzo)
SESSION IV
Pathophysiological modulation of intestinal microenvironment
Chairs:
Massimo Bellini (Italy)
Jan Tack (Belgium)
15:20 Fiber modulation of gut microbiota and biofilms
Mahesh Desai (Luxembourg)
15:45 The gluten spectrum and IBS
Roberto De Giorgio (Italy)
16:10 Probiotics: from history to future
Simone Guglielmetti (Italy)
16:35 Coffee break
16:55 Main Congress Hall Salone del Podestà
FREE PAPERS SESSION
Chairs:
Dan Dumitrascu (Romania)
Francesco Guarner (Spain)
16:55 Post-inflammatory dysbiosis fuels visceral abdominal pain through an altered host-microbiota interaction: mechanistic insights into the effects of faecal microbiota transplantation
Elena Lucarini (Italy)
17:07 Effects of y-aminobutyric acid (GABA) supplementation on symptoms, quality of life, intestinal permeability, systemic inflammation and gut microbiota in patients with IBS-D: a randomized, double blind, placebo-controlled, crossover pilot study
Lorenzo Cancelli (Italy)
17:19 Distinct faecal microbiota signatures in IBS-D patients with bile acid diarrhoea are associated with SeHCAT-defined disease severity
Beatriz Lobo (Spain)
17:31 Clinical Differences Between Irritable Bowel Syndrome and Irritable Bowel Syndrome with Bile Acid Malabsorption in Patients Undergoing SeHCAT Testing
Luigi Colecchia (Italy)
17:43 Adjour
Parallel sessions (different locations)
WORKSHOP 2
14:10 Auditorium Enzo Biagi (Sala Borsa)
SPONSORED LECTURES
Chairs:
Florencia Carbone (Belgium)
Cesare Cremon (Italy)
Vasile Drug (Romania)
14:20 SANOFI SPONSORED LECTURE
Peppermint oil and irritable bowel syndrome
William Fusco (Italy)
14:45 SCHWABE SPONSORED LECTURE
The potential of multu-target plant-based therapies for visceral pain and dysbiosis in patients with DGBI
Giovanni Marasco (Italy)
15:05 GIULIANI SPONSORED LECTURE
Dysbiosis and IBS: pathophysiological implications and evidence-based probiotic strategies
Simone Guglielmetti (Italy)
Loris Lopetuso (Italy)
15:30 Auditorium Enzo Biagi (Sala Borsa)
SESSION IV
Global studies
Chairs:
Florencia Carbone (Belgium)
Cesare Cremon (Italy)
Vasile Drug (Romania)
15:30 Rome V epidemiological studies
Imran Aziz (UK)
15:55 Post-infection DGBI: results from the Rome Foundation Global Epidemiology Study
Giovanni Marasco (Italy)
16:20 Bloating and distension: Asia vs. Europe (AEGIS Study)
Lukas Balsiger (Switzerland)
16:45 Coffee break
17:05 Auditorium Enzo Biagi (Sala Borsa)
FREE PAPERS SESSION
Chairs:
Imran Aziz (UK)
Lukas Balsiger (Switzerland)
17:05 Effectiveness of Digital Nutrition Education Based on NICE Guidelines Versus Nordic Nutrition Recommendations for IBS Over A 12-Month Period: A Randomized Controlled Trial
Kristina Cullman (Sweden)
17:17 Nutritional adequacy and dietary patterns in patients with irritable bowel syndrome with symptoms of avoidant/restrictive food intake disorder
Amanda Blomsten (Sweden)
17:29 Distinct frequencies of small bowel homing B-lymphocytes in patients with IBS
Lukas Balsiger (Belgium)
17:41 Fasting quantitative motor differences and increased postprandial motility index in patients with IBS despite normal small bowel manometry
Christian von Muhlenbrock (Chile)
17:53 Adjour
Parallel sessions (different locations)
WORKSHOP 3
14:20 Oratorio San Giovanni Battista dei Fiorentini
SPONSORED LECTURES
Chairs:
Giovanni Barbara (Italy)
Javier Santos (Spain)
Edoardo Savarino (Italy)
14:20 RECKITT BENCKISER HEALTHCARE SPONSORED LECTURE
Rethinking DGBI through the lens of gut permeability
Javier Santos (Spain)
Edoardo Savarino (Italy)
14:45 CADIGROUP SPONSORED LECTURE
Escherichia Coli Nissle 1917: a century-old probiotic driving modern innovations in gut inflammation control
Giovanni Sarnelli (Italy)
15:10 Oratorio San Giovanni Battista dei Fiorentini
SESSION IV
Pathophysiology, bridging science to patient care
Chairs:
Giovanni Barbara (Italy)
Javier Santos (Spain)
Edoardo Savarino (Italy)
15:10 Mucus and proteases in IBS
Nathalie Vergnolle (France)
15:35 Intestinal, vascular and blood brain barriers in health and disease
Maria Rescigno (Italy)
16:00 Eosinophil activation and IBS
Karen Routhiaux (Belgium)
16:25 Coffee break
16:45 Oratorio San Giovanni Battista dei Fiorentini
FREE PAPERS SESSION
Chairs:
Madhusudan Grover (USA)
Giovanni Sarnelli (Italy)
16:45 Colonic Mast Cell activation is linked to mental and somatic symptom severity in Irritable Bowel Syndrome: results from the DISCOvERIE project
Ana Maria Gonzalez Castro (Spain)
16:57 Transcriptomic and Proteomic profiling of colonic mucosa in patients with irritable bowel syndrome with or without mental/ somatic comorbidities results from the European Multicenter DISCOvERIE study
Carmen Alonso Coroner (Spain)
17:09 Beyond a uniform symptom: anatomical distribution of bloating and associated clinical features, an analysis from the AEGIS study
Jara Lehoucq (Belgium)
17:21 GWAS of stool consistency and in vivo functional validation identify causal genes underlying gut motility
Cristian Diaz-Munoz (Spain)
17:33 Adjour